Pharmacokinetics studies in a short way.

Pharmacokinetics, sometimes described as what the body does to a drug, refers to the movement of a drug in and out of the body. Pharmacokinetics (PK) is the study of drug Absorption, Distribution, Metabolism and Excretion (ADME) processes. Understanding PK properties is essential for drug development and precision dosing. Focusing on the following aspects: Updates on drug-metabolizing enzymes and transporters in PK determination. It provides a new understanding of the transcriptional and post-transcriptional regulatory mechanisms that lead to individual differences in drug therapy. Current status and trends in evaluating drug-drug interactions, especially drug-herb interactions, drug-therapeutic biologic interactions, and microbiota-mediated interactions. Absorption is the process of taking a drug from an administration e.g., Tablets, capsules, into systemic circulation. Absorption affects the speed and concentration with which a drug reaches its intended site of action. There are many possible methods of drug administration including, but not limited to, oral, intravenous, intramuscular, intrathecal, subcutaneous, buccal, rectal, vaginal, ocular, inhalation, aerosol, and transdermal. Distribution describes how a substance is distributed in the body. This depends on the biochemical properties of the drug and the physiology of the person taking the drug. Simply put, the distribution can be influenced by two main factors: Diffusion and convection. Metabolism is the process by which the body processes drugs into the following compounds: It is often used to convert drugs into more water-soluble substances to proceed with renal clearance. Although different metabolic strategies can occur in multiple regions of the body, including the gastrointestinal tract, skin, plasma, kidney, and lung, the majority of metabolism occurs through phase I and phase II reactions in the liver. Excretion is most commonly via the kidneys, but for certain drugs it may be via the lungs, skin, or gastrointestinal tract. In the kidney, drugs are removed by passive glomerular filtration or tubular secretion, which complicates the reabsorption of some compounds. Drug pharmacokinetics depends on both patient-related factors and drug chemistry. Several patient-related factors (eg, renal function, genetic makeup, sex, age) can be used to predict pharmacokinetic parameters in populations. For example, the half-lives of some drugs, especially those that require both metabolism and excretion, can be very long in the elderly. Other factors are related to individual physiology. While the effects of some individual factors (eg, renal failure, obesity, liver failure, dehydration) can be reasonably predicted, others are idiosyncratic and thus have unpredictable effects. Due to individual variability, drug administration has traditionally had to be based on each patient's needs by empirically adjusting dosage until treatment goals are achieved. This approach is often inadequate as it can delay optimal response or cause side effects.

Journal of Pharmaceutical Chemistry and Chemical Science is an Open access Journal accepts articles from across the disciplines including but not limited to Pharmaceutical technology, Pharmacognosy, Pharmaceutics, Molecular modelling, Pharmaceutical Analysis, Organic synthesis, Medicinal chemistry, etc.

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Journal Coordinator
Journal of Pharmaceutical Chemistry and Chemical Science